Peripheral ossifying fibroma is a focal, reactive, nonneoplastic tumorlike growth of the soft tissue that often arises from the interdental papilla 1. Open access journals are freely available online throughout the world, for you to read, download, copy, distribute, and use. More chandramani, thakkar krushna, mukesh asrani2011 cemento ossifying fibroma indian journal of dental research222 5. It is derived from cells of the periodontal ligament and is usually classified as a reactive hyperplasia but sometimes as a benign neoplasm.
Osteofibrous dysplasia is considered as a separate pathological entity in view of its different presentation and treatment, although histopathologically similar to ossifying fibroma. Peripheral ossifying fibroma pof is usually a fibroma. Herein, we report a rare case of a stress fracture through a preexisting non ossifying fibroma nof of the femur of a 12yearold child that raised suspicion of a malignancy. The varying clinical presentations of peripheral ossifying. Ossifying fibroma of the maxilla and sinonasal tract lester dr. First description of ossifying fibroma was given by menzel in 1872 while the term was given by montgomery in 1927. Fibroma article about fibroma by the free dictionary. The term peripheral ossifying fibroma was coined by gardner in 1982 for a lesion that is reactive in nature and is not the extraosseous counterpart of a central ossifying fibroma cof of the.
Article information, pdf download for fibrous dysplasia and. Occasionally treated by curettage enucleation, this conservative. Ossifying fibromas are benign bone lesions that should be differentiated from non ossifying fibromas and fibrous dysplasia. Peripheral ossifying fibroma, also known as ossifying fibrous epulis, is a gingival nodule which is composed of a cellular fibroblastic connective tissue stroma which is associated with the formation of randomly dispersed foci of mineralised products, which consists of bone, cementumlike tissue, or a dystrophic calcification. Pofs are frequently associated with irritants like calculus, plaque. Pofs comprises of, one or more mineralized tissues, including bone, cementum like material or dystrophic calcification, within a matrix of cellular fibroblastic tissue 2. Pof typically presented as a solitary, slow growing nodular mass that is either pedunculated or sessile.
Juvenile psammomatoid ossifying fibroma jpof is an uncommon benign boneforming neoplasm in the craniofacial skeleton of juvenile patients and defined as a variant of ossifying fibroma of. At 18 months follow up, she was symptom free with almost full range of active elbow. A nof is a result from failure of the bone to properly close at its outer shell. The clinicopathologic characteristics of multiple ossifying fibroma of are unclear. Central ossifying fibroma is a benign slowgrowing tumor of mesenchymal origin and it tends to occur in the second and third decades of life, with predilection for women and for the mandibular premolar and molar areas. Volume 74, issue 12, december 2016, pages 24092419. Menzel first described the lesion ossifying fibroma in 1872 5, but its terminology was given by montgomery in 1927. One patient with midface posj aged 17 years died, and the other one 22 years old was diseasefree at followup. Bone andor cementum may be present in an ossifying fibroma, and so cemento ossifying fibroma cof may also be used interchangeably. Ossifying fibroma of the nose and paranasal sinuses. Introduction peripheral ossifying fibroma is a nonneoplastic.
Peripheral ossifying fibroma is a gingival growth, usually arising from interdental papilla and occurring frequently in the anterior maxilla. Juvenile psammomatoid ossifying fibroma jpof of proximal. Juvenile psammomatoid ossifying fibroma jpof is a rare benign osseous. Radiographs taken after 7 mo b, 1 year c, 1 year and 7 mo d, and 2 years and 7 mo e together reveal the location of the lesion became more distal with growth of the child. When encountered in a painful area, especially if combined with atypical radiographic features, they may mimic a. It was first described as relatively uncommon, solitary, nonneoplastic gingival growth by eversol and robin. It is often considered to be a type of fibroosseous lesion fol. Ossifying fibromas ofs are benign fibroosseous pathologies of. This paper highlights the diverse clinical and histopathological presentations of peripheral ossifying fibroma through three cases encountered. The central type of ossifying fibroma arises from the endosteum or the periodontal ligament. Peripheral ossifying fibroma pof is a gingival nodule composed of a cellular fibroblastic connective tissue stroma associated with the formation of randomly dispersed foci of a mineralized product consisting of either bone woven and lamellar. Peripheral ossifying fibroma a clinical and histological. Pdf peripheral ossifying fibroma is a reactive gingival overgrowth whose pathogenesis is uncertain. They tend to persist or increase in size as the child grows but decrease in size or close once growth ends.
We report in this study, the clinical report of a 20yrold male patient with a peripheral ossifying fibroma i n the maxilla exhibiting significant size with the disease duration of 1 year. Malignant transformation of ossifying fibroma into parosteal. The condition is often clinically ambiguous when diagnosed. Fibrous dysplasia and juvenile psammomatoid ossifying fibroma. Intraoral ossifying fibromas have been described in the literature since the late 1940s. It has been distinguished from a larger group of ossifying fibromas on the basis of age of the patients, site of involvement and clinical behaviour. The ossifying fibroma of is a benign neoplasm that affects the jaws. Peripheral ossifying fibroma is a rejuvenation of the reactive gingiva, usually occurring in the anterior maxillary gingiva.
In the present study, we report the clinical data in the case of a 46yearold female patient, treated due to 5day forehead swelling accompanied by dizziness. The peripheral ossifying fibroma is one such lesion. Peripheral ossifying fibroma represents a separate clinical entity rather than a transitional form of pyogenic granuloma, peripheral giant cell fibroma and irritational fibroma. Peripheral ossifying fibroma pof is a focal, reactive, nonneoplastic tumorlike growth of the soft tissue occurring frequently in the maxillary anterior region, mainly affects females, predominating in the second decade of life. Juvenile ossifying fibroma international journal of medical and. Open access journals are freely available online throughout the world, for you to read, download, copy.
Peripheral ossifying fibroma is one such reactive lesion, for which the etiology is unclear. The varying clinical presentations of peripheral ossifying fibroma. S, ravi david austin department of oral medicine and radiology, rajah muthiah dental college and hospital, annamalai university, chidambaram, tamil nadu, india 608002. Juvenile psammomatoid ossifying fibroma jpof is a rare fibroosseous lesion that. Gingival enlargement, differential diagnosis, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, prognosis. Peripheral ossifying fibroma pof is a reactive gingival overgrowth which is relatively uncommon in nature. The most distinguishing feature of the ossifying fibroma is the wellcircumscribed appearance of the ossifying fibroma radiographically, clinically, and the ease with which it can be separated from normal bone surgically. Terminology in the 2005 who histological classification of odontogeni. Peripheral cementoossifying fibroma is a reactive gingival overgrowth occurring frequently in anterior maxilla. This article is from diagnostic pathology, volume 9. Histopathologic differential diagnoses thorakkal shamim department of dentistry, government taluk head quarters hospital, nilambur, india peripheral ossifying fibroma is a benign neoplasm that usually develops from gingiva, presenting as an. Peripheral ossifying fibroma pof is a nonneoplastic enlargement of gingiva that is classified as a reactive hyperplastic inflammatory lesion. Cdc73 gene mutations in sporadic ossifying fibroma of the jaws.
Head and neck ossifying fibroma of is a rare, benign, locally aggressive, fibroosseous tumor. However, the marked cellularity of jofpo is in sharp contrast to the usually stromarich appearance of the latter group of lesions. Ossifying fibroma definition of ossifying fibroma by. The term ossifying fibroma includes lesions with similar histological compositions and different forms of clinical behavior. It represents upto 2% of all lesions that are biopsied. Peripheral cementoossifying fibroma of maxilla ncbi. Juvenile psammomatoid ossifying fibroma of the paranasal. Ossifying fibroma is a benign bone neoplasm often considered to be a type of fibroosseous lesion.
Ossifying fibromas are benign asymptomatic neoplasms of the maxillae that generally have slow growth and present proliferation of fibrous cell tissue, with a varying quantity of bone products that include bone, cement or a combination of these. The standard textbooks devote no space to descriptions characterizing ossifying fibromas of the frontal sinuses. Lesions with histological features similar to pof have been given various. They are noncancerous and do not spread to other areas of the body. Nov 10, 2015 the purpose of the present article was to present a clinical case of an 11yearold girl with peripheral ossifying fibroma pof. By convention the term ossifying fibroma generally refers to the cemento ossifying type, which is associated with toothbearing. Cemento ossifying fibroma of the jaw dental jounal424 3. There was considerable confusion in the terminology used in the literature until it was distinguished. Massive ossifying fibroma of mandible pubmed central pmc. Campanacci described this condition in two leg bones, the tibia and fibula, and coined the term. Histopathologic examination is needed in order to positively identify the lesion. Orthopaedic institute for children nonossifying fibroma. Figure 1 plain radiographs of a non ossifying fibroma in the humerus of a 4yearold female.
Central ossifying fibroma is a lesion in which diagnosis has proved intriguing and unclear for presenting clinical, radiographic, and even. Juvenile ossifying fibroma of mandible free full text. Although nofs are very frequent, in the vast majority of cases, they are completely asymptomatic. Ossifying fibroma is a rare benign fibroosseous neoplasm of the jaw characterized by substitution of normal bone by fibrous tissues and newly formed calcified products such as bone, cementum or both. Careful diagnosis of peripheral ossifying fibroma is important to avoid unnecessary aggressive therapy. Peripheral ossifying fibroma is a reactive gingival overgrowth occurring frequently in the anterior maxilla in teenagers and young adults. Trabecular type of juvenile ossifying fibroma a rare case. Clinically, it is a large asymptomatic tumor of aggressive appearance, with possible tooth displacement. Fibroosseous lesions of the jaws, including juvenile ossifying fibroma, pose diagnostic and therapeutic difficulties due to their clinical, radiological and. Peripheral ossifying fibroma pof is usually a fibroma of the gingival which shows areas of calcification or ossification. According to the world health organization, it is pro posed that benign fibro osseous lesions be divided into 3 categories, including fibrous dysplasia, ossifying. Ossifying fibroma of is classified as, and behaves like, a benign bone neoplasm. Fibrous dysplasia and ossifying fibroma of the paranasal.
Ossifying fibroma an overview sciencedirect topics. Conclusion juvenile ossifying fibroma is an aggressive lesion which. They most often arise from the tooth bearing areas of these bones. Ossifying fibromas of the craniofacial skeleton intechopen. An osteolytic lesion is shown at the cortex in the proximal humerus a. A nonossifying fibroma nof is one of the most common benign bone tumors found in 30 to 40% of children between 820 years of age.
Cementoossifying fibroma radiology reference article. Osseous dysplasia and fibrous dysplasia are reactive lesions while ossifying fibroma is a true neoplasm. Two cases of multiple ossifying fibromas in the jaws. Extensive presentation of central ossifying fibroma treated. Due to its clinical and histopathological similarities, some pofs are believed to develop initially as a pyogenic granuloma that. Find, read and cite all the research you need on researchgate. Cureus a nonossifying fibroma and a stress fracture of. In consequence, the fibroosseous lesions present different biological behavior 1, 2.
What is peripheral ossifying fibroma peripheral ossifying fibroma is a benign swelling of the gum, most commonly seen in teenagers and young adults. This condition should be differentiated from nonossifying fibroma and fibrous dysplasia of bone. Its origin is believed to be from periodontal membrane, and it shows more predilection toward females. Cemento ossifying fibroma cof are rare, benign neoplasms that usually arise from the mandible or maxilla.
319 283 1591 172 1563 1024 443 789 551 816 664 1355 60 88 234 936 122 1518 1078 617 404 1215 151 920 383 1263 169 981 1108 777 1149 1530 828 1364 1193 1139 1377 372 976 1127 56 183 663 698 1418 1470 788 809 905